Pyr6

SKU: orb1307828

Description

Pyr6 is a selective TRPC3 channel inhibitor with an IC50 of 0.49 µM, demonstrating higher potency against CRAC-mediated calcium entry. This compound is a valuable research tool for studying receptor-operated calcium signaling in cellular models, including mast cell and immune cell research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 245747-08-4
• MW: 418.27
• Purity: 99.18% (May vary between batches)
• Formula: C₁₇H₉F₇N₄O
• SMILES: Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
• Target: Calcium Channel,TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (23.91 mM);DMSO:95 mg/mL (227.13 mM)

Bioactivity

• Target IC50:
  TRPC3:0.49 uM
• In Vitro:
  Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency. By contrast, Pyr6 exhibited a 37-fold higher potency to inhibit Orai1-mediated Ca(2+) entry as compared with TRPC3-mediated Ca(2+) entry and potently suppressed mast cell activation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide, Pyr 6, Pyr6, Pyr-6, inhibit, Transient receptor potential channels, TRP Channel, TRPC3, TRPChannel, TRPVChannel, TRPV Channel

Compound Identifiers

PubChem CID

10598093