Pyr10

SKU: orb1307830

Description

Pyr10

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1315323-00-2
• MW: 449.37
• Purity: 99.70% (May vary between batches)
• Formula: C₁₈H₁₃F₆N₃O₂S
• SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
• Target: TRP/TRPV Channel
• Solubility: DMSO:95 mg/mL (211.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.34 mM)

Bioactivity

• Target IC50:
  TRPC3:0.72 μM
• In Vivo:
  Pyr10 blunted ventricular CF activation and MF in l-NAME hypertensive mice. Finally, TRPC3 was present in human ventricular CFs and upregulated in MF, whereas pharmacological modulation of TRPC3-NFATc3 decreased proliferation and collagen secretion. TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management.
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• In Vitro:
  The novel pyrazole Pyr10 displayed substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

fibroblast, Orai, l-NAME, Inhibitor, inhibit, cardiac, Ca2+, Transient receptor potential channels, TRPVChannel, TRPV Channel, TRPC3, TRPChannel, TRP Channel, Pyr 10, Pyr10, Pyr-10, pyrazole, SOCE, STIM1, ROCE

Compound Identifiers

PubChem CID

53475435