PXS 64

SKU: orb3211525

Description

PXS 64 is a mannitol-6-phosphate (M6P) analog and lipophilic prodrug of PXS 25. It effectively exerts antifibrotic effects by inhibiting the activation of latent TGF-β1. In human lung fibroblasts, PXS 64 suppresses fibrosis via the TGF-β1 pathway. It reduces the expression of TGFβ-mediated collagen IV, fibronectin, MCP-1, and phosphorylated smad2 in kidney cells while also decreasing collagen deposition in dermal scar fibroblasts. PXS 64 is applicable to research on chronic kidney disease, idiopathic pulmonary fibrosis, and scar formation.

Key Properties

• CAS Number: 1253691-50-7
• MW: 590.60
• Formula: C₂₇H₄₃O₁₂P
• SMILES: O([C@H]1O[C@H](CCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)[C@@H](O)[C@H](O)[C@@H]1O)C2=C(C)C=C(C)C=C2
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TGF-beta/Smad