PXS-6302 hydrochloride

SKU: orb1945022

Description

PXS-6302 hydrochloride is a potent, irreversible pan-lysyl oxidase (LOX) family inhibitor with IC50 values ranging from 0.3 to 3.7 μM across LOX and LOXL1-4 isoforms. Its ability to penetrate skin and reduce collagen accumulation makes it a valuable research tool for investigating fibrotic diseases and scar formation in both in vitro and in vivo models.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 2584947-79-3
• MW: 301.71
• Purity: 99.98% (May vary between batches)
• Formula: C₁₀H₁₁ClF₃NO₂S
• SMILES: S(C(/C(=C/CN)/F)(F)F)(=O)(=O)C1=CC=CC=C1.Cl
• Target: Lipoxygenase,Monoamine Oxidase
• Solubility: DMSO: 50 mg/mL (165.72 mM), Sonication is recommended.

Bioactivity

• In Vivo:
  PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application.
• In Vitro:
  PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PXS-6302 hydrochloride (2584947-54-4 Free base), PXS 6302 Hydrochloride, PXS6302 Hydrochloride, PXS-6302 Hydrochloride, LOX, 2584947-54-4, 2584947-54-4 Free base

Chemical structure of PXS-6302 hydrochloride

Compound Identifiers

PubChem CID

155585071