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PX-478

SKU: orb1224246

Description

A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity; inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively; suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.Blood Cancer Phase 1 Discontinued.

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Key Properties

CAS Number685898-44-6
MW394.1215
Purity>98% (HPLC)
FormulaC13H20Cl4N2O3
SMILESCl.Cl.N[C@@H](CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O |r,c:5,7,t:3|
TargetHIF/HIF Prolyl-hydroxylase
SolubilityH2O: ≥ 35 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PX478 | PX 478

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Protocol Information

PX-478 (orb1224246)

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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 310.00
50 mg
$ 400.00
100 mg
$ 620.00