PX-478

SKU: orb1224246

Description

A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity; inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively; suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.Blood Cancer Phase 1 Discontinued.

Key Properties

• CAS Number: 685898-44-6
• MW: 394.1215
• Purity: >98% (HPLC)
• Formula: C₁₃H₂₀Cl₄N₂O₃
• SMILES: Cl.Cl.N[C@@H](CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O |r,c:5,7,t:3|
• Target: HIF/HIF Prolyl-hydroxylase
• Solubility: H2O: ≥ 35 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PX478 | PX 478

Quick Database Links

Gene Symbol

HIF/HIF Prolyl-hydroxylase