PX-12

• Catalog Number: orb1305801
• Category: Small Molecules
• Description: PX-12
• Purity: 99.60%
• MW: 188.31
• Biological Activity: PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.
• CAS Number: [141400-58-0]
• Formula: C₇H₁₂N₂S₂
• SMILES: CCC(C)SSc1ncc[nH]1
• Storage: -20°C
• Note: For research use only