PW0464 ((Rac)-Razpipadon) is a potent, non-catechol, and G protein-biased dopamine D1 receptor agonist (Gs-cAMP EC50 = 5.8 nM). It serves as a valuable research tool for investigating D1R signaling in neurological disorders, with applications in both in vitro signaling studies and in vivo models of Parkinson's disease and cognitive dysfunction.