PW0464

SKU: orb1693301

Description

PW0464 ((Rac)-Razpipadon) is a potent, non-catechol, and G protein-biased dopamine D1 receptor agonist (Gs-cAMP EC50 = 5.8 nM). It serves as a valuable research tool for investigating D1R signaling in neurological disorders, with applications in both in vitro signaling studies and in vivo models of Parkinson's disease and cognitive dysfunction.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1643462-93-4
• MW: 389.35
• Purity: 98.78%
• Formula: C₁₉H₁₇F₂N₃O₄
• SMILES: O=C1NC(=O)N(C(C=2C=CC(OC3=NC=CC=C3OC(F)F)=CC2C)=C1C)C
• Target: Dopamine Receptor
• Solubility: 10% DMSO+90% Corn Oil:1.5 mg/mL (3.85 mM);DMSO:18 mg/mL (46.23 mM)

Bioactivity

• Target IC50:
  cAMP assay (HEK293T cells):5.8 nM (EC₅₀)
• In Vitro:
  PW0464 is a non-catechol selective dopamine D1/D5 receptor agonist. In HEK293T cells overexpressing D1R or D5R, PW0464 activates G-protein signaling (cAMP production) with an EC₅₀ of 5.8 nM, indicating high potency.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Rac)-Razpipadon, PW 0464, PW0464, PW-0464

Compound Identifiers

PubChem CID

86764103