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Purvalanol B

SKU: orb1225672

Description

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.

Images & Validation

Key Properties

CAS Number212844-54-7
MW432.9039
Purity>98% (HPLC)
FormulaC20H25ClN6O3
SMILESCC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=C(C(O)=O)C=C3)=C2N=C1
TargetCDK
SolubilityDMSO: ≥ 40 mg/mL

Bioactivity

In Vitro
Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC50 of 7.07 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NG-95

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Quality Guarantee

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Purvalanol B (orb1225672)

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500 mg
5 mg
$ 120.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 320.00
100 mg
$ 470.00
200 mg
$ 690.00