Punicalagin

SKU: orb1303562

Description

Punicalagin

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 65995-63-3
• MW: 1084.72
• Purity: 99.70%
• Formula: C₄₈H₂₈O₃₀
• SMILES: O=C1C=2C=3C=4C5=C(C=6C(=CC(O)=C(O)C6O)C(=O)OCC(O)C(OC(=O)C=7C(C2C(O)=C(O)C3OC5=O)=C(O)C(O)=C(O)C7)C8C(C=O)OC(=O)C=9C(C=%10C(C(=O)O8)=CC(O)=C(O)C%10O)=C(O)C(O)=C(O)C9)C(O)=C(O)C4O1
• Target: SARS-CoV,HBV
• Solubility: H2O:100 mg/mL (92.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.61 mM);DMSO:260 mg/mL (239.69 mM)

Bioactivity

• Target IC50:
  HT29 cells:100-200 μM|PLpro:> 50 μM|SARS-CoV-2:7.20 μM (EC50)|LoVo cells:100-200 μM|3CLpro:6.192 μg/ml
• In Vivo:
  METHODS: To stud the effects on MTX-induced hepatotoxicity in mice, Punicalagin (25-50 mg/kg, 0.5% CMC) was administered orally to Swiss albino mice once daily for ten days, followed by a single dose of MTX (20 mg/kg) injected intraperitoneally o the seventh day. Results: Punicalagin significantly attenuated MTX-induced elevation of serum aminotransferases, ALP, and LDH, as well as hepatic oxidative stress measures, and enhanced hepatic antioxidant defense. In MTX-induced mouse liver, Punicalagin inhibited oxidative damage, inflammation and apoptosis and upregulated Nrf2.
• In Vitro:
  METHODS: Human cervical cells ME-180 were treated with Punicalagin (10-100 µM) for 24 h. Cell viability was measured by MTT assay. Results: Punicalagin showed significant concentration dependent cytotoxicity against ME-180 cells the cell viability of Punicalagin-treated cells was reduced by approximately 80% compared to control cells. METHODS: Human cervical cancer cells the HeLa, were treated with Punicalagin (25-100 µM) for 36 h the cell cycle was detected by Flow cytometry. Results the number of G1-phase cells increased significantly after 36 h of Punicalagin treatment.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

anticancer, Antioxidant, anti-inflammatory, inhibit, ingredient, Inhibitor, Hepatitis B virus, HBV, Pomegranate, polyphenol, Punicalagin, SARS coronavirus, SARSCoV, SARS-CoV

Compound Identifiers

PubChem CID

16129719