Pulrodemstat benzenesulfonate

SKU: orb1309468

Description

Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is an orally bioavailable, potent inhibitor of lysine-specific demethylase 1 (LSD1). It demonstrates anticancer activity and is utilized in research fields such as oncology and epigenetics, with studies exploring its effects in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2097523-60-7
• MW: 609.64
• Purity: 97.73% (May vary between batches)
• Formula: C₃₀H₂₉F₂N₅O₅S
• SMILES: OS(=O)(=O)c1ccccc1.COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1
• Target: Histone Demethylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.28 mM);DMSO:60 mg/mL (98.42 mM)

Bioactivity

• Target IC50:
  LSD1:0.25 nM (IC50)
• In Vivo:
  LSD1-IN-7 in combination with other LSD1 inhibitor can be treatment of cancer in a mammal, including breast cancer, lung cancer, prostate cancer, glioblastoma, or leukemia.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HistoneDemethylase, Histone Demethylase, inhibit, Lysine specific demethylase-1 (LSD1), LSD1-IN-7 benzenesulfonate, LSD1, oral, differentiation, cell, CC90011, CC-90011, CC-90011 benzenesulfonate, CC 90011, anticancer, AML, reversible, Pulrodemstat, Pulrodemstat benzenesulfonate, SCLC

Compound Identifiers

PubChem CID

129096972