PUC-10

SKU: orb3028724

Description

PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. Computer simulations suggest that PUC-10 is orally active and capable of crossing the blood-brain barrier. It induces autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 is applicable in the study of neurological disorders.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2095549-31-6
• MW: 541.661
• Formula: C₃₁H₃₁N₃O₄S
• SMILES: S(=O)(=O)(N1C=2C(C([C@@H](CN3CCN(CC3)C4=C(OC)C=CC=C4)O)=C1)=CC=CC2)C=5C6=C(C=CC5)C=CC=C6
• Target: 5-HT Receptor,Autophagy,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor,Autophagy,mTOR