PU-H71 HCl

SKU: orb1819130

Description

PU-H71 HCl (Zelavespib HCl) is a purine-scaffold Hsp90 inhibitor and radiosensitizer with demonstrated antitumor activity in preclinical models. It impairs DNA double-strand break repair by downregulating key proteins like Rad51 and Ku70, relevant to homologous recombination and non-homologous end joining pathways. Its efficacy has been studied in various in vitro and in vivo cancer models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2095432-24-7
• MW: 548.83
• Purity: 99.45%
• Formula: C₁₈H₂₂ClIN₆O₂S
• SMILES: Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C(=NC=NC4N3CCCNC(C)C)N
• Target: DNA/RNA Synthesis,HSP
• Solubility: DMSO:45 mg/mL (81.99 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, HSP90, RNA Synthesis, RNASynthesis, PU-H71 HCl, PU-H71 HCl(873436-91-0 Free base), RAD51, Zelavespib HCl

Compound Identifiers

PubChem CID

54613037