PTPN2/1-IN-4

SKU: orb3173832

Description

PTPN2/1-IN-4 (Compound WS35) is an orally active dual inhibitor of PTPN1 and PTPN2, with IC50 values of 12.8 nM and 5.8 nM, respectively. It modulates the IFNγ-JAK-STAT signaling pathway and significantly enhances CD8+ T cell tumor infiltration. PTPN2/1-IN-4 demonstrates potent anticancer activity, effectively inhibiting tumor growth in the B16-OVA syngeneic mouse model both as a monotherapy and in combination with anti-PD-1 antibody treatment.

Key Properties

• CAS Number: 3093350-55-8
• MW: 422.48
• Formula: C₁₉H₂₃FN₄O₄S
• SMILES: O=C1NS(=O)(=O)N(C2=C(F)C=C(C=C2O)C=3C=NC(NCCC(C)C)=C(C3)C)C1
• Target: IFNAR,STAT,JAK,Phosphatase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

IFNAR,STAT,JAK,Phosphatase