PTPN2-IN-2

SKU: orb3174475

Description

PTPN2-IN-2 is a potent and orally bioavailable PTPN2 inhibitor with an IC50 of 7.05 nM, which enhances the IFN-γ signaling pathway. It also inhibits PTP1B with an IC50 of 9.88 nM. In the B16-OVA mouse model, PTPN2-IN-2 suppresses tumor growth and promotes the activation and infiltration of tumor immune cells. This compound is applicable in melanoma research.

Key Properties

• CAS Number: 3093350-44-5
• MW: 451.47
• Formula: C₁₉H₂₂FN₅O₅S
• SMILES: O=C(NC1CCCCCC1)C2=NC=C(N2)C=3C=C(F)C(=C(O)C3)N4CC(=O)NS4(=O)=O
• Target: JAK,Phosphatase,IFNAR,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JAK,Phosphatase,IFNAR,STAT