PTP1B-IN-9

SKU: orb1220094

Description

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM.

Research Area

Cell Biology

Key Properties

• CAS Number: 145888-79-5
• MW: 413.1
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₃Cl₄NO?
• SMILES: ClC1=CC=C(\\C=C2/CNC\\C(=C/C3=CC(Cl)=C(Cl)C=C3)C2=O)C=C1Cl
• Target: Proteasome
• Solubility: In Vitro: DMSO : 5 mg/mL (12.10 mM)

Bioactivity

• In Vitro:
  RAMB4 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively. RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM. Cell Viability Assay Cell line: Keratinocytes, SiHa, CaSki and ME180 cells. Concentration: 5, 10, 15, 20, 25, 30 μM. Incubation time: 48 hours. Result: Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Proteasome