PTP1B-IN-33

SKU: orb3173004

Description

PTP1B-IN-33 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 2.45 μM against human PTP1B, showing more than 20-fold selectivity over SHP2. It enhances π-alkyl interactions with PTP1B, thereby promoting closure of the WPD loop. PTP1B-IN-33 can be used in studies on cancer, diabetes, and autoimmune deficiency diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 77500-30-2
• MW: 306.32
• Purity: 99.93% (May vary between batches)
• Formula: C₁₈H₁₄N₂O₃
• SMILES: O=C(NC=1C=CC=CC1)C=2OC(=CC2)C(=O)NC=3C=CC=CC3
• Target: Phosphatase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase