PTP1B-IN-2

SKU: orb1303017

Description

PTP1B-IN-2 is a potent small molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC50 of 50 nM. It is a valuable research tool for studying PTP1B's role in diabetes and obesity, with applications in both in vitro enzymatic assays and cellular studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1919853-46-5
• MW: 680.79
• Purity: 99.58%
• Formula: C₃₄H₃₆N₂O₉S₂
• SMILES: COC(=O)CN(c1ccc(CN(c2ccc(OCc3ccc(C)cc3)c(c2)C(=O)OC)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O
• Target: Phosphatase
• Solubility: DMSO:45 mg/mL (66.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.94 mM)

Bioactivity

• Target IC50:
  PTP1B:50 nM
• In Vitro:
  PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PTP1B IN 2, PTP1BIN2, PTP-1B-IN-2, PTP1B-IN-2, PTP1B, Phosphatase

Compound Identifiers

PubChem CID

127050086