Pt(II)-NHC complex 2C

SKU: orb3174606

Description

Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic carbene complex 2C) (Compound 2C) is an N-heterocyclic carbene-based platinum (II) complex. This compound acts as an immunogenic cell death (ICD) inducer in liver cancer cells, triggering endoplasmic reticulum stress (ERS) and ROS production, which ultimately leads to the release of damage-associated molecular patterns (DAMPs). Furthermore, it arrests the cell cycle in the S phase and significantly induces apoptosis. In mouse models, Pt(II)-NHC Complex 2C has demonstrated anticancer potential against liver cancer and activated immune cells in liver injury models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 3035433-94-1
• MW: 840.36
• Formula: C₂₄H₂₃F₂I₂N₃Pt
• SMILES: FC=1C=CC(=CC1)C2=C(C3=CC=C(F)C=C3)N([C-2](N2CC)=[Pt+4]([I-])([I-])[N]=4C=CC=CC4)CC
• Target: ROS,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Apoptosis