PTD10

SKU: orb2278131

Description

PTD10 is a potent PROTAC BTK degrader with sub-nanomolar DC50 and KD values, effectively degrading BTK and inhibiting proliferation in B-cell lines like Ramos and JeKo-1. It induces apoptosis via caspase and mitochondrial pathways, making it a valuable tool for studying B-cell malignancies and dysregulation in vitro.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2642231-19-2
• MW: 922.99
• Purity: 99.12% (May vary between batches)
• Formula: C₄₉H₅₁N₁₁O₈
• SMILES: O=C1C=2N(C3=C(C2)CC(C)(C)C3)CCN1C4=C(CO)C(=CC=N4)C=5C=C(NC6=CC=C(C=N6)N7[C@@H](C)CN(C(CNC8=C9C(C(=O)N(C9=O)C%10C(=O)NC(=O)CC%10)=CC=C8)=O)CC7)C(=O)N(C)C5
• Target: BTK,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156735923