PTC-209

SKU: orb1225326

Description

PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).

Key Properties

• CAS Number: 315704-66-6
• MW: 495.19
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃Br₂N₅OS
• SMILES: COC1=CC(Br)=C(NC2=NC(=CS2)C2=C(C)N=C3N=CC=CN23)C(Br)=C1
• Target: BMI-1
• Solubility: DMSO: 99 mg/mL (199.92 mM)

Bioactivity

• In Vivo:
  Animal model: Nude mice (male, aged 8-10 weeks, HCT1116 cell-derived tumor). Dosage: 60 mg/kg body weight. Administration: Subcutaneously; once a day for 11 days. Result: Significantly reduced tumor volume.
• In Vitro:
  Cell Viability Assay Cell line: Lung (LNM35, A549 cells), breast (MDA-MB-231 and T47D cells), and colon (HT-29, HCT-116, and HCT8/S11 cells). Concentration: 0.01-10 μM Incubation time: 24, 48, and 72 hour. Result: Induced a concentration- and time-dependent decrease in the cellular viability of all cell lines tested.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BMI-1