PT-65

SKU: orb2283341

Description

PT-65 is a potent and selective degrader of GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells. This molecule is a valuable chemical tool for investigating GSK3's role in Alzheimer's disease pathology and related neurodegenerative research in cellular models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2721998-87-2
• MW: 1082.19
• Formula: C₅₁H₆₃N₁₃O₁₂S
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCCOCCN4C=C(CCCCN5CCN(S(=O)(=O)C6=CC=C(C=C6)C7=NC(C(NC=8C=CC=NC8)=O)=C(N)N=C7)CC5)N=N4
• Target: Others,GSK-3,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166636245