PT-129

SKU: orb2944386

Description

PT-129 is a PROTAC degrader targeting the G3BP1/2 NTF2 domain to disrupt stress granule assembly and disassemble existing granules. This action inhibits ATF4-mediated signaling between fibroblasts and cancer cells, providing a tool for studying cancer cell stress resilience and tumor-stroma communication in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 936.98
• Formula: C₄₆H₄₈N₈O₁₂S
• SMILES: O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3NCCOCCOCCOCCC(NC4=CC=C(NC([C@H](CC5=CC=CC=C5)NS(=O)(CC(N6C(C=CC=C7)=C7C=N6)=O)=O)=O)C=C4)=O
• Target: PROTACs,GTPase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,GTPase