PSN 375963

SKU: orb1305698

Description

PSN 375963 hydrochloride is a synthetic GPR119 agonist used in research to study metabolic pathways. It is applied in both in vitro assays and in vivo models to investigate its potential role in glucose homeostasis and insulin secretion.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 388575-52-8
• MW: 285.38
• Purity: 99.24%
• Formula: C₁₇H₂₃N₃O
• SMILES: CCCCC1CCC(CC1)c1nc(no1)-c1ccncc1
• Target: GPCR
• Solubility: DMSO:4 mg/mL (14.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.5 mM);Ethanol:24 mg/mL (84.1 mM)

Bioactivity

• Target IC50:
  GPR119:7.9 μM(EC50,mouse)|GPR119:8.4(EC50,human)
• In Vivo:
  PSN 375963 suppressed food intake in rats and reduced body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats.
• In Vitro:
  PSN 375963 is a potent GPR119 agonist with EC50s of 8.4 and 7.9 μM for human and mouse GPR119.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cAMP, orphan, endogenous, GPR119, G Protein-Coupled Receptor 119, PSN375963, PSN-375963, PSN375963 Hydrochloride, PSN-375963 Hydrochloride, PSN 375963, PSN 375963 hydrochloride

Compound Identifiers

PubChem CID

2875918