Pseudoginsenoside F11

SKU: orb1221865

Description

Pseudoginsenoside-F11 is a component of Panax quinquefolium (American ginseng), can antagonize the learning and memory deficits induced by scopolamine, morphine, and methamphetamine in mice.

Key Properties

• CAS Number: 69884-00-0
• MW: 801.01
• Purity: >98% (HPLC)
• Formula: C₄₂H₇₂O₁₄
• SMILES: O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)O)O)O)O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O[C@@H]1[C@H]2C([C@H](CC[C@@]2([C@@H]2[C@@](C1)([C@@]1(CC[C@@H]([C@H]1[C@@H](C2)O)[C@]1(O[C@H](CC1)C(C)(C)O)C)C)C)C)O)(C)C
• Target: Others
• Solubility: DMSO : 100 mg/mL 124.84 mM; H2O : 0.67 mg/mL 0.84 mM

Bioactivity

• In Vivo:
  One In vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage. We tested the effects of Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using In vivo microdialysis. As the results shown, Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine.
• In Vitro:
  Biochemical experiments revealed that Pseudoginsenoside F11 (Ginsenoside A1) could inhibit diprenorphine (DIP) binding with an IC50 of6.1 μM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-μ cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ginsenoside A1

Quick Database Links

Gene Symbol

Others