Pseudocoptisine chloride

SKU: orb1297839

Description

Pseudocoptisine chloride

Research Area

Neuroscience

Key Properties

• CAS Number: 30044-78-1
• MW: 355.77
• Purity: 99.94%
• Formula: C₁₉H₁₄ClNO₄
• SMILES: [Cl-].C1Oc2cc3CC[n+]4cc5cc6OCOc6cc5cc4-c3cc2O1
• Target: Cholinesterase (ChE)
• Solubility: DMSO:1 mg/mL (2.81 mM)

Bioactivity

• Target IC50:
  AChE:12.8 μM
• In Vivo:
  Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test.
• In Vitro:
  In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), cytokines, AChE, anti-inflammatory, anti-amnestic, Isocoptisine, Isocoptisine Chloride, Isocoptisine chloride, inhibit, Inhibitor, RAW 264.7, pro-inflammatory, Pseudocoptisine, Pseudocoptisine chloride, Pseudocoptisine Chloride

Compound Identifiers

PubChem CID

85777785