PSD-95/nNOS PPI-IN-1

SKU: orb3180332

Description

PSD-95/nNOS PPI-IN-1 is an inhibitor targeting the interaction between PSD-95 and nNOS, potentially crossing the blood-brain barrier. It binds with high affinity to the PSD-95 PDZ2 domain (Ki= 19.45 μM). By reducing intracellular ROS levels and inhibiting apoptosis, it counteracts glutamate-induced excitotoxicity. In rat tMCAO models, PSD-95/nNOS PPI-IN-1 significantly decreases brain infarct volume. This compound is useful for research in acute ischemic stroke.

Images & Validation

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Key Properties

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Target	Apoptosis,NO Synthase,ROS,iGluR

Storage & Handling

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Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Apoptosis,NO Synthase,ROS,iGluR

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