PSB-12379 ditriethylamine salt

SKU: orb1708792

Description

PSB-12379 ditriethylamine salt is a potent and selective inhibitor of Ecto-5'-Nucleotidase (CD73), exhibiting low nanomolar Kis of 2.21 nM (human) and 9.03 nM (rat). This nucleotide analogue is a valuable research tool for investigating CD73 function in oncology and immunology, supporting both in vitro enzymatic assays and in vivo disease model studies.

Research Area

Immunology & Inflammation

Key Properties

• MW: 717.73
• Purity: 99.97% (May vary between batches)
• Formula: C₃₀H₅₃N₇O₉P₂
• SMILES: O=P(CP(O)(O)=O)(O)OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@@H]1N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2.CCN(CC)CC.CCN(CC)CC
• Target: CD73
• Solubility: DMSO:11 mg/mL (15.33 mM)

Bioactivity

• In Vitro:
  Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD73, PSB12379 disodium, PSB-12379 ditriethylamine, PSB 12379 disodium

Compound Identifiers

PubChem CID

168011909