PSB-06126

SKU: orb1704198

Description

PSB-06126 is a potent and selective NTPDase3 inhibitor, exhibiting a Ki of 1.5 μM for the rat enzyme. This tool compound is valuable for in vitro and in vivo studies exploring the role of extracellular nucleotide signaling in cancer immunology and immune-related disorders.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 1052089-16-3
• MW: 466.44
• Purity: 99.59% (May vary between batches)
• Formula: C₂₄H₁₅N₂NaO₅S
• SMILES: O=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]
• Target: Phosphatase,Immunology/Inflammation related
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.58 mM);Ethanol:<23.32 mg/mL;DMSO:100 mg/mL (214.39 mM)

Bioactivity

• Target IC50:
  NTPDase1 (rat):0.33 μM (Ki)|NTPDase3 (human):4.39 μM (Ki)|NTPDase2 (rat):19.1 μM (Ki)|NTPDase3 (rat):2.22 μM (Ki)
• In Vitro:
  In mesenchymal stem cells (MSCs), PSB-06126 (3 μM) can block the overexpression of NTPDase3. PSB-06126 increases extracellular ATP levels by activating P2X7 and P2Y6 receptors, ultimately promoting osteogenic differentiation and mineralization of MSCs.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PSB 06126, PSB06126, PSB-06126

Compound Identifiers

PubChem CID

87158209