PS372424 hydrochloride

SKU: orb3027219

Description

PS372424 hydrochloride is a synthetic tripeptide agonist of the human CXCR3 receptor derived from CXCL10. It exhibits anti-inflammatory properties by inhibiting T-cell migration, as demonstrated in humanized models of arthritic inflammation. This compound is a valuable research tool for studying CXCR3-mediated immune responses in both in vitro and in vivo contexts.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1596362-29-6
• MW: 625.2
• Purity: 95.03% (May vary between batches)
• Formula: C₃₃H₄₅ClN₆O₄
• SMILES: C(N[C@H](C(NCC1CCCCC1)=O)CCCNC(=N)N)(=O)[C@H]2N(C(CCC(=O)C3=CC=CC=C3)=O)CC=4C(C2)=CC=CC4.Cl
• Target: CXCR
• Solubility: DMSO:200 mg/mL (319.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8 mM)

Bioactivity

• In Vitro:
  In cells expressing CXCR3-A, stimulation with PS372424 hydrochloride resulted in a peak in intracellular calcium levels after 20 seconds, and after 5 minutes of stimulation, PS372424 increased phosphorylated p-Erk1 and phosphorylated p-Erk2 in U87-CXCR3-A cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PS 372424 hydrochloride

Quick Database Links

Gene Symbol

CXCR