Prunin

SKU: orb1297228

Description

Prunin (Naringenin 7-O-glucoside) is a soluble flavonoid with research applications in metabolic and microbiological studies. It demonstrates anti-diabetic potential by inhibiting PTP1B and enhancing glucose uptake in vitro, while also showing modulatory effects on bacterial growth. Its activity against HMG-CoA reductase is relevant for lipid metabolism research.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 529-55-5
• MW: 434.39
• Purity: 99.52%
• Formula: C₂₁H₂₂O₁₀
• SMILES: OC[C@H]1O[C@@H](Oc2cc(O)c3C(=O)C[C@@H](Oc3c2)c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Virus Protease,Phosphatase,Anti-infection
• Solubility: DMSO:25 mg/mL (57.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.6 mM)

Bioactivity

• In Vitro:
  The effects of Prunin- and HG-alkyl (C4-C18) esters (0.1-100μM) on human leukemia T (Jurkat) cells viability and plasma membrane fluidity were evaluated. At this concentration, cell hyperpolarization and shrinkage were also observed. Cell plasma membrane fluidity was not affected, regardless the depths of the membrane level evaluated, but mild changes in plasma membrane hydration were found. Esterification did not affect the antioxidant capacity of Prunin and HG (0.1-10μM) against 1mM H2O2. When exposed to 1mM AAPH, P-alkyl esters retained Prunin antioxidant capacity, but HG-derivatives acted as pro-oxidants

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-diabetic, Antifection, Antiinfection, Anti-infection, Naringenin 7-0-glucoside, inhibit, infection, HEV, HEVs, Inhibitor, HMG-CoA reductase, HRV, HRVs, Enterovirus, Virus Protease, VirusProtease, RNA, Prunin, Rhinovirus, synthesis, Phosphatase

Compound Identifiers

PubChem CID

40473202