Prunetin

• Catalog Number: orb1302338
• Category: Small Molecules
• Description: Prunetin
• Purity: 98.43%
• MW: 284.26
• Biological Activity: 1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
• CAS Number: [552-59-0]
• Formula: C₁₆H₁₂O₅
• SMILES: COc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O
• Storage: -20°C
• Note: For research use only