Proxyphylline

SKU: orb1301392

Description

Proxyphylline is a xanthine derivative functioning as a dual adenosine A1/A2a receptor antagonist and phosphodiesterase inhibitor. It is utilized in research as a bronchodilator, vasodilator, and cardiac stimulant for investigating respiratory and cardiovascular pathways in experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 603-00-9
• MW: 238.243
• Purity: 99.79% (May vary between batches)
• Formula: C₁₀H₁₄N₄O₃
• SMILES: O=C(N1C)N(C)C2=C(N(CC(O)C)C=N2)C1=O
• Target: PDE,Adenosine Receptor
• Solubility: DMSO:70 mg/mL (293.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.39 mM)

Bioactivity

• In Vitro:
  Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-(2-Hydroxypropyl)theophylline, A2A, A1, Adenosine Receptor, AdenosineReceptor, Inhibitor, PDE, inhibit, Proxyphylline, P1 receptor

Compound Identifiers

PubChem CID

4977