Protosappanin A

SKU: orb1297669

Description

Protosappanin A

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 102036-28-2
• MW: 272.25
• Purity: 100.00%
• Formula: C₁₅H₁₂O₅
• SMILES: Oc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1
• Target: IκB/IKK,NADPH-oxidase,JAK,TNF,ROS,HIV Protease,NO Synthase,COX,STAT,IL Receptor,NF-κB,TLR,Interleukin
• Solubility: DMSO:225 mg/mL (826.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.37 mM)

Bioactivity

• Target IC50:
  HIV-1 (IN):12.6 uM
• In Vitro:
  Protosappanin A (PsA) and Protosappanin B (PsB) were identified from Sappan Lignum extracts. They showed activity against both S. aureus and MRSA with MIC or MIC50 at 64 (PsA) and 128 (PsB) mg/L alone. When they were used in combination with antibiotics, they showed the best synergy with amikacin and gentamicin with MIC50 (mg/L) of amikacin reduced more significantly from 32 to four (with PsA) and eight (with PsB), and the fractional inhibitory concentration index (FICI) ranged between 0.078 and 0.500 (FICI50 = 0.375). Moreover, the resistance of MRSA towards amikacin and gentamicin could be reversed by the Clinical and Laboratory Standards Institute criteria. The combined bactericidal mode could as well be synergy. PsA and PsB showed very low cytotoxicity in comparison with their promising activity against MRSA.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NO Synthase, NO, NF-κB, NADPHoxidase, NADPH-oxidase, NFkB, NFκB, NF-kB, inhibit, NOSynthase, IL Receptor, ILReceptor, IκB, JAK, Janus kinase, IFN-γ, Inhibitor, HIV-1, HIV-1 IN, HIV Protease, HIVProtease, IkB, IKK, IkB/IKK, TLR, ROS, PTA, Protosappanin A, TNF-α, STAT

Compound Identifiers

PubChem CID

128001