Protohypericin

SKU: orb1297229

Description

Protohypericin is a photocytotoxic naphthodianthrone from Hypericum perforatum. Its radioiodinated derivative is investigated for targeted tumor radiotherapy, with applications in studying photodynamic therapy mechanisms in both in vitro and in vivo cancer research models.

Key Properties

• CAS Number: 548-03-8
• MW: 506.46
• Purity: 98.56% (May vary between batches)
• Formula: C₃₀H₁₈O₈
• SMILES: Cc1cc(O)c2c(c1)c1c3c4cc(C)cc(O)c4c(=O)c4c(O)cc(O)c(c5c(O)cc(O)c(c15)c2=O)c34
• Target: Others
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vitro:
  The experimental work was performed in specific filtered light conditions that prevented both an unintended photoconversion of Protohypericin and photosensitization of the cells. Assessing the photocytotoxicity as a function of irradiation time, it was found that the photocytotoxicity of both compounds converged after a long irradiation time (i.e., 15 min), while the difference between the photocytotoxicities was maximal after a short irradiation time (i.e., 1 min)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NSCLC, naphthodianthrone, Inhibitor, Protohypericin

Compound Identifiers

PubChem CID

164660