Protamine sulfate

SKU: orb1690167

Description

Protamine sulfate is a polycationic peptide known for its ability to neutralize heparin's anticoagulant activity. It is widely utilized in research for establishing cystitis models in vivo and enhancing transfection efficiency in vitro for gene delivery studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 9009-65-8
• Purity: 99.87% (May vary between batches)
• Target: Thrombin
• Solubility: H2O:45 mg/mL

Bioactivity

• In Vitro:
  Protamine sulfate, a 5-kDa cationic polypeptide derived from salmon sperm, demonstrates a concentration-dependent, partial, and reversible inhibitory effect on thrombin's ability to convert fibrinogen to fibrin. This compound also binds negatively charged unfractionated heparin (UFH), concurrently downregulating thrombin generation through the inhibition of factor V activation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protamine sulfate, Protamine Sulfate, Thrombin

Quick Database Links

Gene Symbol

Thrombin