PROTAC VHL-type degrader-1

SKU: orb2564607

Description

PROTACVHL-type degrader-1 is a VHL-recruiting PROTAC that induces ATM degradation. This activity synergizes with the ATR inhibitor AZD6738, a combination studied in vitro for cancer research, particularly in the context of DNA damage response pathways.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2821804-13-9
• MW: 898.08
• Formula: C₄₉H₅₅N₉O₆S
• SMILES: O=C1\C(\C=2C(N1CCCC3=CN(CCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)N=N3)=CC=CC2)=C\7/C=8C(NC7=O)=CC=CC8
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171714290