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PROTAC TEAD1/IAP degrader-1

SKU: orb3211417

Description

PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective PROTAC-based degrader targeting TEAD1 and cIAP1, with DC50 values of 14 nM and 270 nM, respectively. This compound facilitates the ubiquitination and degradation of TEAD1 and cIAP1, and it reduces the expression of the TEAD-dependent gene CTGF. Additionally, PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma.

Images & Validation

Key Properties

TargetYAP,PROTACs,IAP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information