PROTAC SOS1 degrader-5

SKU: orb2565416

Description

PROTAC SOS1 degrader-5 (compound 4) potently degrades SOS1 with a DC50 of 13 nM and inhibits NCI-H358 cell proliferation with an IC50 of 5 nM. This molecule is a valuable chemical probe for investigating SOS1-dependent RAS signaling in cancer research, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2836273-61-9
• MW: 872.93
• Formula: C₄₅H₅₁F₃N₈O₇
• SMILES: C(OC1=CC2=C(C=C1OC)N=C(C)N=C2N[C@H](C)C3=CC(C(F)(F)F)=CC(N)=C3)C4(CN(C(CCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)C)CC4
• Target: Ras,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170836244