PROTAC SMARCA2/4-degrader-9

SKU: orb2664366

Description

PROTAC SMARCA2/4-degrader-9 (I-503) is a heterobifunctional molecule that selectively degrades the SMARCA2 and SMARCA4 ATPase subunits of the SWI/SNF chromatin remodeling complex. It demonstrates potent degradation (DC50 < 100 nM) in cellular models like MV411 and A549, serving as a critical chemical probe for oncology and epigenetics research.

Research Area

Neuroscience

Key Properties

• CAS Number: 2568507-15-1
• MW: 914.13
• Formula: C₄₉H₅₉N₁₁O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5CCC(C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155390878