PROTAC SMARCA2/4-degrader-6

SKU: orb2664305

Description

PROTACSMARCA2/4-degrader-6 (I-438) is a heterobifunctional degrader that selectively targets SMARCA2 and SMARCA4 proteins for proteasomal degradation. It serves as a valuable chemical probe for investigating SWI/SNF chromatin remodeling complex function in oncology research, with utility demonstrated in both cellular and in vivo models.

Images & Validation

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Key Properties

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CAS Number	2568277-87-0
MW	928.16
Formula	C₅₀H₆₁N₁₁O₅S
SMILES	NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@@H]5CC[C@@H](C(N[C@H](C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

155405143 ↗

Key Properties

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No computed properties available.

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