PROTAC SMARCA2/4-degrader-6

SKU: orb2664305

Description

PROTACSMARCA2/4-degrader-6 (I-438) is a heterobifunctional degrader that selectively targets SMARCA2 and SMARCA4 proteins for proteasomal degradation. It serves as a valuable chemical probe for investigating SWI/SNF chromatin remodeling complex function in oncology research, with utility demonstrated in both cellular and in vivo models.

Research Area

Neuroscience

Key Properties

• CAS Number: 2568277-87-0
• MW: 928.16
• Formula: C₅₀H₆₁N₁₁O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@@H]5CC[C@@H](C(N[C@H](C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155405143