PROTAC SMARCA2/4-degrader-11

SKU: orb2664329

Description

SMARCA2 degrader-1 (I-321) is a potent PROTAC molecule that effectively degrades SMARCA2 with a DC50 below 100 nM. Its bifunctional design links a SMARCA inhibitor to an E3 ligase ligand, enabling targeted protein degradation for probing SMARCA2 biology in cancer research models, both in vitro and in vivo.

Research Area

Neuroscience

Key Properties

• CAS Number: 2568276-71-9
• MW: 675.78
• Formula: C₃₇H₄₁N₉O₄
• SMILES: O=C1NC(=O)C(N2C(=O)N(C=3C2=CC=CC3C4CCC(N5CCC(N6N=CC(=C6)C=7C=C(N=NC7N)C=8C=CC=CC8O)CC5)CC4)C)CC1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167386794