PROTAC SMARCA2/4-degrader-1

SKU: orb2664946

Description

SMARCA2/4-degrader-1 (I-430) is a potent PROTAC inducing profound degradation of SMARCA2 and SMARCA4 proteins, with DC50 values below 100 nM and >90% Dmax in A549 cells. This tool compound is valuable for oncology research, particularly in studying SWI/SNF complex function in vitro.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2568273-68-5
• MW: 971.18
• Formula: C₅₁H₆₂N₁₂O₆S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@H]5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=C(NC(C)=O)C=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155390783