PROTAC SMARCA2 degrader-12

SKU: orb2665010

Description

SMARCA2 degrader-13 (compound I-406) acts as a PROTAC degrader targeting SMARCA2. It exhibits a DC50 of less than 100 nM for the degradation of SMARCA2 protein in A549 cells, achieving a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2568277-42-7
• MW: 912.11
• Formula: C₄₉H₅₇N₁₁O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C=5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155404871