PROTAC SMARCA2 degrader-12

SKU: orb2665010

Description

SMARCA2 degrader-13 (I-406) is a potent and selective PROTAC that induces rapid degradation of SMARCA2 protein, with a DC50 <100 nM and >90% Dmax in A549 cells. This tool compound is valuable for in vitro studies exploring SMARCA2-dependent oncology and synthetic lethality in SMARCA4-deficient cancers.

Research Area

Neuroscience

Key Properties

• CAS Number: 2568277-42-7
• MW: 912.11
• Formula: C₄₉H₅₇N₁₁O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C=5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155404871