PROTAC Sirt2 Degrader-1

SKU: orb1988939

Description

PROTAC Sirt2 Degrader-1 is a heterobifunctional molecule that selectively degrades Sirt2 by linking a potent Sirt2 inhibitor to a cereblon E3 ligase ligand. It exhibits high selectivity with an IC50 of 0.25 µM for Sirt2 over Sirt1/3. This tool compound is used in vitro and in vivo to study Sirt2's role in cancer, neurodegeneration, and other cellular processes.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2098487-75-1
• MW: 852.94
• Formula: C₄₀H₄₀N₁₀O₈S₂
• SMILES: Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1
• Target: PROTACs,Sirtuin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135397670