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PROTAC ROR1 degrader-1

SKU: orb2945034

Description

PROTACROR1degrader-1 (Compound 11d) is a bifunctional PROTAC molecule that selectively targets and degrades the pseudokinase ROR1 with a DC50 of 40-80 nM in NSCLC cells. It induces apoptosis and PARP cleavage in NCI-H23 cells, making it a valuable chemical tool for studying ROR1 biology and targeted protein degradation in cancer research.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW1081.22
FormulaC55H74BrN11O5S
TargetPROTACs,ROR,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information