PROTAC PI3K/110β degrader-2

SKU: orb3135201

Description

PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3070438-79-5
• MW: 948.18
• Formula: C₅₁H₆₅N₉O₇S
• SMILES: C(NC1=C(C(NCCCCCCC(N[C@H](C(=O)N2[C@H](C(NCC3=CC=C(C=C3)C=4SC=NC4C)=O)C[C@@H](O)C2)C(C)(C)C)=O)=O)C=CC=C1)(C)C=5C=6N(C(=O)C=C(N6)N7CCOCC7)C=C(C)C5
• Target: P-gp,PI3K,Akt,ATPase,ROS,PROTACs,Bcl-2 Family,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp,PI3K,Akt,ATPase,ROS,PROTACs,Bcl-2 Family,Apoptosis