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PROTAC PI3Kα/δ degrader-1

SKU: orb3210608

Description

PROTAC PI3Kα/δ degrader-1 is an orally active PI3Kα/δ PROTAC degrader with IC50 values of 0.34 nM for PI3Kα and 1.85 nM for PI3Kδ. It inhibits cancer cell proliferation and migration, induces G1 phase cell cycle arrest, and facilitates PI3Kα degradation. In addition, PROTAC PI3Kα/δ degrader-1 suppresses tumor growth in breast cancer xenograft mouse models and is applicable to breast cancer research.

Images & Validation

Key Properties

TargetPROTACs,PI3K

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information