PROTAC PDE4 degrader-1

SKU: orb3135657

Description

PROTACPDE4 degrader-1 (Compound 9m) is an orally active, selective PDEC4 PROTAC degrader with a DC50 of 41.98 μM. It effectively inhibits the secretion of pro-inflammatory cytokines, such as TNF-α and IL-6, and significantly reduces pulmonary inflammation in a mouse model of LPS-induced acute lung injury (ALI).

Research Area

Signal Transduction

Images & Validation

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Key Properties

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Target	PDE,Interleukin,PROTACs,TNF

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PDE,Interleukin,PROTACs,TNF

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