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PROTAC PDE4 degrader-1

SKU: orb3135657

Description

PROTACPDE4 degrader-1 (Compound 9m) is an orally active, selective PDEC4 PROTAC degrader with a DC50 of 41.98 μM. It effectively inhibits the secretion of pro-inflammatory cytokines, such as TNF-α and IL-6, and significantly reduces pulmonary inflammation in a mouse model of LPS-induced acute lung injury (ALI).

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

TargetInterleukin,PROTACs,TNF,PDE

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information