PROTAC PARP1 degrader-5

SKU: orb3210938

Description

PROTAC PARP1 degrader-5 is a PARP1 PROTAC degrader with a DC50 of 0.12 μM. This compound promotes the sustained degradation of PARP1 by harnessing the ubiquitin-proteasome system through the catalytic formation of a ternary complex. It induces DNA damage, resulting in the accumulation of minimal amounts of cytoplasmic double-stranded DNA within tumor cells and increases PD-L1 expression on their surface. When encapsulated in lipid nanoparticles, PROTAC PARP1 degrader-5 demonstrates tumor growth inhibition in a mouse melanoma model. This compound is applicable in cancer research, including studies on melanoma.

Key Properties

• Target: PD-1/PD-L1,DNA/RNA Synthesis,PARP,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,DNA/RNA Synthesis,PARP,PROTACs