PROTAC PARP1 degrader-2

SKU: orb2663950

Description

PROTACPARP1 degrader-2 (Compound 72) is a potent and cell-permeable PARP-targeting PROTAC, demonstrating a DC50 below 10 nM in MDA-MB-231 cells and inhibiting viability in MDA-MB-436 cells with an IC50 under 100 nM. It serves as a valuable chemical tool for investigating PARP biology and targeted protein degradation in cancer research models, both in vitro and in vivo.

Key Properties

• CAS Number: 2923686-62-6
• MW: 753.75
• Formula: C₃₈H₃₇F₂N₉O₆
• SMILES: O=C(NC1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1)C5=NC(F)=C(C=C5)N6CCN(CC=7C=CC=8N=C(C(=O)NC8C7F)C)CC6

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168228760